Bimatoprost Online


Ophthalmological medication Bimatoprost eye drops for sale



How and where to order Bimatoprost (Latisse, Lumigan, Careprost) ophthalmic solution 0.03% 3 ml online:

MEDICINES STORE

from $19.95 per bottle
10% discount coupon: MSD10


GENERIC DRUGS SHOP

from $24.30 per bottle
15% discount coupon: qRr3ZyvhPv


PHARMA SHOP

from $33.31 per bottle
10% discount coupon: hf-5478




LUMIGAN (BIMATOPROST) OPHTHALMIC SOLUTION 0.01% AND 0.03%: CLINICAL PHARMACOLOGY (see "References")

Mechanism of Action

Bimatoprost (Lumigan), a prostaglandin analog, is a synthetic structural analog of prostaglandin with ocular hypotensive activity. It selectively mimics the effects of naturally occurring substances, prostamides. Bimatoprost is believed to lower intraocular pressure (IOP) in humans by increasing outflow of aqueous humor through both the trabecular meshwork and uveoscleral routes. Elevated IOP presents a major risk factor for glaucomatous field loss. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss.

Pharmacokinetics

Absorption

After one drop of bimatoprost ophthalmic solution 0.03% was administered once daily to both eyes of 15 healthy subjects for two weeks, blood concentrations peaked within 10 minutes after dosing and were below the lower limit of detection (0.025 ng/mL) in most subjects within 1.5 hours after dosing. Mean Cmax and AUC024hr values were similar on days 7 and 14 at approximately 0.08 ng/mL and 0.09 ng•hr/mL, respectively, indicating that steady state was reached during the first week of ocular dosing. There was no significant systemic drug accumulation over time.

Distribution

Lumigan (Bimatoprost) is moderately distributed into body tissues with a steady-state volume of distribution of 0.67 L/kg. In human blood, bimatoprost resides mainly in the plasma. Approximately 12% of bimatoprost remains unbound in human plasma.

Metabolism

Bimatoprost is the major circulating species in the blood once it reaches the systemic circulation following ocular dosing. Bimatoprost then undergoes oxidation, Ndeethylation and glucuronidation to form a diverse variety of metabolites.

Elimination

Following an intravenous dose of radiolabeled bimatoprost (3.12 mcg/kg) to six healthy subjects, the maximum blood concentration of unchanged drug was 12.2 ng/mL and decreased rapidly with an elimination half-life of approximately 45 minutes. The total blood clearance of bimatoprost was 1.5 L/hr/kg. Up to 67% of the administered dose was excreted in the urine while 25% of the dose was recovered in the feces.



Lumigan (Bimatoprost) related pharmaceutical drugs and medications

Trade name of the drug Pharmaceutical forms and doses Companies
Travatan (Travoprost) clinical pharmacology
  • Solution; Ophthalmic; Travoprost 0.004%
  • Alcon
  • Summit
  • Brimonidine Sandoz
  • Solution; Ophthalmic; Brimonidine Tartrate 0.2%
  • Sandoz


  • Recent posts:

  • Lumigan prescribing information



    Disclaimer: Please note, this website is not an online pharmacy, drugstore and related online pharma shop. It does not sell, supply or advertise any prescription and OTC drugs, medications, other goods and services. All reviews, links, lists, databases, texts, and other content on the website are provided free and only for informational and educational purposes. Medical content on this website, including drug names, indications, contraindication, side effects, categories, classifications, forms, doses, prices, other health and pharmaceutical information are taken only from trusted and authoritative professional sources (see "References"), reviewed and prepared by our licensed experts, content inspectors and editors.
    You should always consult your doctor or other healthcare professional before using any medication. This website, our staff and support do not provide own medical instructions and advices.
    All brands and trade names appearing on the website are registered trademarks of their respective companies.
    Remember that buying drugs and medicines online is a responsibility only of customers, sellers and suppliers regarding existing legislation in their jurisdictions.

    Share us in social media:

    Copyright © 2014-2019 BimatoprostBuyOnline.com, a division of Pharma-Doctor.com pharmaceutical network. All rights reserved.

    Home Page | Privacy Policy | Cookies Policy | Terms of Service | Contact Us