Bimatoprost Online


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Cheap qualitative Bimatoprost ophthalmic solution 0.03% 3 ml bottles



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LATISSE (BIMATOPROST) OPHTHALMIC SOLUTION 0.03%: PRESCRIBING INFORMATION

DESCRIPTION

Latisse (Bimatoprost ophthalmic solution) 0.03% is a synthetic prostaglandin analog. Its chemical name is (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3S)-3hydroxy-5-phenyl-1-pentenyl]cyclopentyl]-5-Nethylheptenamide, and its molecular weight is 415.58. Its molecular formula is C25H37NO4.

Bimatoprost is a powder, which is very soluble in ethyl alcohol and methyl alcohol and slightly soluble in water. Latisse is a clear, isotonic, colorless, sterile ophthalmic solution with an osmolality of approximately 290 mOsmol/kg.

Active ingredients: Bimatoprost 0.3 mg/mL (0.03%)

Preservative: Benzalkonium Chloride 0.05 mg/mL

Inactive ingredients: sodium phosphate dibasic; sodium chloride; citric acid; purified water. Sodium hydroxide and/or hydrochloric acid may be added to adjust pH. The pH during its shelf life ranges from 6.8 - 7.8.


DOSAGE AND ADMINISTRATION

Latisse dosage and administration


INDICATIONS AND USAGE

Latisse (Bimatoprost ophthalmic solution) 0.03% is indicated to treat hypotrichosis of the eyelashes by increasing their growth including length, thickness and darkness.


CONTRAINDICATIONS

Hypersensitivity Latisse (Bimatoprost ophthalmic solution) is contraindicated in patients with hypersensitivity to bimatoprost or any other ingredient in this product.


WARNINGS

Latisse warnings


PRECAUTIONS

Latisse precautions


ADVERSE REACTIONS

Latisse adverse reactions


USE IN SPECIFIC POPULATIONS

Latisse use in specific populations


CLINICAL PHARMACOLOGY

Latisse clinical pharmacology


NONCLINICAL TOXICOLOGY

Carcinogenesis, Mutagenesis, Impairment of Fertility

Latisse (Bimatoprost) ophthalmic solution was not carcinogenic in either mice or rats when administered by oral gavage at doses of up to 2 mg/kg/day and 1 mg/kg/day respectively (approximately 192 and 291 times the recommended human exposure based on blood AUC levels after topical corneal and/or conjunctival sac administration respectively) for 104 weeks.

Bimatoprost was not mutagenic or clastogenic in the Ames test, in the mouse lymphoma test, or in the in vivo mouse micronucleus tests.

Latisse (Bimatoprost) eye drops did not impair fertility in male or female rats up to doses of 0.6 mg/kg/day.


CLINICAL STUDIES

Latisse clinical studies


HOW SUPPLIED / STORAGE AND HANDLING

Latisse (Bimatoprost ophthalmic solution) 0.03% is supplied sterile in opaque white low density polyethylene dispenser bottles and tips with turquoise polystyrene caps accompanied by 60 sterile, disposable applicators: 3 ml of solution in a 5 ml bottle.

Storage

Latisse should be stored at 2° to 25°C (36° to 77°F).

Manufactured and distributed by Allergan pharmaceutical company and its divisions.

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